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KMID : 0605720070130020340
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 2 p.340 ~ p.345
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A Case Report of Olanzapine-Associated Transient Diabetic Ketoacidosis in a 14 Years Old Boy of Bipolar Disorder
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Seo Wan-Seok
Kim Jin-Sung
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Abstract
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We reported an olanzapine-associated transient diabetic ketoacidosis and diabetes mellitus case of a 14-year-old boy with Bipolar disorder. He has been relatively stable with 10㎎ of olanzapine but, he had severe weight gain, from 52㎏ to 113.6 in 3 and a half years. He was lethargy and complained dry mouth, coughing, insomnia from since 7days before admission. He was transferred to emergency room because of mentality change. Important laboratory findings were as follows：PH 7.289 at ABGA, serum glucose level 1,179㎎/dL, ketone 5.6m㏖/L. He was diagnosed as DM and DKA and supplied fluid & insulin. His mentality and all laboratory findings except serum glucose level were become to normal in three days. His symptoms of bipolar were man-aged with topiramate, gquetiapine, aripiprazole instead of olanzapine. This is the first case report of olnazapine-associated diabetic ketoacidosis in pediatric patient with bipolar disorder in Korea. This case report suggested that when olanzapine was used in pediatric population, regular monitoring of serum glucose level and body weight change, understanding of early warnings signs of DM and DKA should be needed.
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KEYWORD
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Olanzapine, Weight gain, Diabetic ketoaccidosis, Metabolic syndrome
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